"We've got to push back on what Iran is doing in the region, we've got to be tougher with Iran and we've got to fix the flaws in the deal".
President Hassan Rouhani has said Iran would be willing not to abandon its nuclear deal even if the United States pulls out, providing the European Union offers guarantees that Tehran would keep benefiting from the accord.
The decision that Mr Trump has to make by May 12 is whether or not to reimpose American sanctions on Iran.
Mr. Trump has set a Saturday deadline to decide whether to pull out of the Obama-era agreement that lifted economic sanctions on Iran in return for halting the Islamic regime's nuclear program until 2025.
"We are determined to save this deal because this accord safeguards against nuclear proliferation and is the right way to stop Iran getting a nuclear weapon", Le Drian said. "America is making a mistake if it leaves the nuclear accord".
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Mr Rouhani's remarks came ahead of President Donald Trump's decision expected later this week on whether to pull the USA out of the landmark deal between Iran and world powers.
Boris Johnson, the British Foreign Secretary, has warned that an arms race could develop in the Middle East if the USA backs out of the Iranian nuclear agreement.
TRT World's Ira Spitzer reports more on this latest development from Berlin. German Foreign Minister Heiko Maas said it was clear that the agreement made the world securer and there was a risk of escalation were it to be cancelled.
Maas said that the world was safer with the agreement than without it and that the European signatories to the deal had prepared good recommendations for their USA partners.