The commentator was battling cancer.
But Krauthammer was arguably a Renaissance man, achieving mastery in such disparate fields as psychiatry, speech-writing, print journalism and television.
Krauthammer, a Pulitzer Prize victor and commentator, died at the age of 68.
He also was a regular on Fox News for several years.
Less than a month earlier, Krauthammer had told a Fox colleague that the worst appeared to be behind him. "I had thought that silence would soon be coming to an end, but I'm afraid I must tell you now that fate has decided on a different course for me".
News of Krauthammer's death brought reactions from conservative politicians and personalities. "It was a long and hard fight with many setbacks, but I was steadily, if slowly, overcoming each obstacle along the way and gradually making my way back to health ..."
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His death was confirmed by his manager Taylor Maglin , who took to Facebook to pay tribute to his "brother". According to WTAE , the 21-year-old, born Travon Smart, was one of the victims in a double shooting.
Less than a year later, he wrote a letter to his colleagues at the Washington Post announcing the cancer had returned. "There was no sign of it as recently as a month ago, which means it is aggressive and spreading rapidly".
Krauthammer announced on June 8 that doctors had given him just weeks to live. This is the final verdict.
Krauthammer had been a columnist at The Washington Post since 1984. "I am sad to leave, but I leave with the knowledge that I lived the life that I intended".
He wrote in the Post column that he left his life with no regrets.
"I made one promise to myself on day one - I was not going to allow it to alter my life", he said.