Jeremy Hunt arrives for a Cabinet meeting chaired by British Prime Minister Theresa May at 10 Downing Street on June 5, 2018 in London, England.
Hours later UK Foreign Minister Boris Johnson resigned over the political crisis.
While Davis said he wanted Theresa May to stay as prime minister, with Johnson's later resignation May's position has become more fragile than ever, only a few days after seeming to find consensus in her cabinet for her soft Brexit plan at Chequers, May's official country residence. "The dream is dying, suffocated by needless self-doubt", he wrote.
May elected Brexit campaigner Dominic Raab as Davis' replacement, but concerns over her longevity persist. "In that respect we are truly headed for the status of colony".
The reshuffle is expected to continue as Mrs May attempts to stamp her authorities following the Chequers summit last Friday.
Katie Bylis continued: 'As for the ongoing Brexit negotiations, it's now evens that no deal will be reached by the March 2019 deadline and if any other key players leave the Tory Party then those odds will shorten even further'.
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The Chequers plan would give a say to the EU's top court, would have the United Kingdom abide by European Union agriculture rules and make other pledges not to undercut the European Union in standards, proposes a customs partnership with the bloc and intends to essentially keep the United Kingdom part of the single market with regards to goods.
Mrs May told MPs that the plan agreed by the cabinet at Chequers was the basis of a "responsible and credible" offer to restart renegotiations with the EU.
Brexit-supporting lawmakers were angered by the proposals, saying they would keep Britain tethered to the bloc and unable to change its rules to strike new trade deals around the world.
But it remains unclear whether the European Union will accept her negotiating bid on a free trade area for goods.
The UK and the European Union have been negotiating Brexit terms for more than a year now and have been hoping to agree broad aims for their future relationship in October.
But leading pro-Brexit legislator Jacob Rees-Mogg said "I don't think a no-confidence vote is immediately in the offing".
Under Conservative Party rules, a leadership race could be triggered if at least 48 of her MPs declared their support for one.