Lovren and Kane are set to meet again in Moscow on Wednesday, less than nine months after the former was substituted in the first half as Liverpool were crushed by Tottenham at Wembley in the Premier League.
And the centre-back was far from pleased when a reporter asked if he was anxious about the prospect of another meeting with Kane.
"I don't know what to say". "It's completely irrelevant, that one defeat against Spurs".
'I've got the utmost respect for him - he's been banging goals in for Spurs for several seasons - but he's not alone, his team-mates play at top clubs, so it will be hard. You're nitpicking at my poor performances. He is showing all the attributes to be a world-class striker.
"I'm proud to make ex-players proud and I'm sure it's bringing back memories for them". Croatia has never reached the final, while England triumphed at the World Cup once in 1966.
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Lovren, though, does not think fatigue will prove a problem against England.
He said: "I've been locked in a room for two days watching Croatia play - I've only left for meals and to do TV or radio work - I think we can beat them".
"I'm perfectly ready and fit".
Belgium were excellent against Brazil but I am anxious that game might have been their performance of this World Cup. We know what's at stake and in such moments you forget any fatigue you may feel because this is maybe a once-in-a-lifetime opportunity.
"FIFA's priority remains the health of everyone involved in the operation and we will look into finding a new opportunity to invite the boys to a Federation Internationale de Football Association event to share with them a moment of communion and celebration", a spokesperson said.