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Like Federer and Anderson, Nadal and del Potro Nadal slugged it out for more than four pulsating hours before Spain's 17-times major victor finally landed the knockout punch.
There's no doubt Djokovic will be the fresher of the two when they meet on Friday, after Del Potro took a lot out of Nadal.
Victory on Wednesday gave Nadal his 11th win in 16 meetings against the fifth seed Del Potro as the Spaniard stayed on course for an 18th Grand Slam title.
He eventually finished off the world No.53 in the third tiebreak to move into his second Wimbledon quarter-final where twice champion Nadal is waiting.
"There is no one other match in the history of tennis that has been played more than our match. I've only lost one match", said Nadal.
"We have always considered him an ambassador and he continues to wave the flag".
Having crashed out in the first round at Wimbledon for five consecutive times, Goerges' emotions spilled over at the end of the match after she embraced Bertens at the net.
Djokovic leads 26-25 in their head-to-head, dominating in recent times with seven victories in the past nine matches.
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Add in Nadal, 32, and Djokovic, 31, and it's the first time in the half-century of professional tennis that all four male semifinalists at any Slam are in their 30s.
"I play Los Cabos in Mexico - the beach", he smiled.
The two-time victor will meet Novak Djokovic in the last four on Friday.
"You know that you can't win against him if you don't play very well".
And he served it out to book a tie with three-time champion Djokovic.
Djokovic, however, has surprised many with his surge to the last four, although he reached the final of the pre-Wimbledon warm-up event at Queen's last month.
However, the 12th seed has looked focused and close to his best form on his way to reaching a first Slam semi-final since the 2016 US Open. I'm really happy for you.
"I will try to hold my service games most of the time".
A significant part of the problem was a painful right elbow that forced him off the tour for the second half of 2017 after he stopped playing during his Wimbledon quarterfinal.
But Nadal was first to break in the deciding set and he built a 5-3 advantage with a looped forehand victor before confirming his final four place with a volley after four hours and 48 minutes.