Ten people were killed and over 70 passengers were injured when a train came off the rails in northwest Turkey Sunday, Demiroren news agency reported.
Turkish media quoted Health Minister Ahmet Demircan as saying 338 people required hospital treatment after the accident with 124 still hospitalised.
Emergency services, military and ambulance helicopters arrived at the scene.
Television images showed several wagons laying on their side and emergency personnel walking to reach the crash site.
'The accident happened because of adverse weather conditions, ' he added.
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According to reports, the train was travelling from Uzunkopru to Instanbul and came off the rails in the Tekirdag Corlu district.
President Tayyip Erdogan's office said he had received information from the ministers of transport and interior about the incident, and sent condolences for those killed.
Erdogan said all state institutions were "using every means available to help" in a statement issued by the presidency, as he vowed that there would be a comprehensive investigation into the "tragic accident".
Turkish passengers have in general preferred taking planes or buses for intercity travel, but this has been changing with the new high-speed lines.
Later, the Ministry of Transport said in a statement the accident occurred after the railway track slipped down from its original spot due to torrential rains.
The train was headed to Istanbul.