"Yesterday was tough for several reasons, I had a stomach virus, went to bathroom at the end of the second set and threw up, and last night I didn't eat anything", Zverev admitted. There was no going back there for me.
Although the Australian fended off a match point, he was unable to save the second, with Nadal approached the net playing a backhand volley to seal the win. Both matches were played on clay.
Even in a tournament that has featured a bloodbath of seeds, this was a particularly savage shock.
Ostapenko lost only one more game as she progressed to a second consecutive Wimbledon quarterfinal. The match today showed I can't take anything for granted. "I was feeling physically really good". We played in dark for an hour.
Edmund appeared to be riding a wave of euphoria generated by England's World Cup quarter-final win against Sweden as he outplayed the Serbian former World No. 1 in the first set. I felt my mind go, you know, and move on. Probably the experience kicked in'. But he's going to find his way.
Gulbis said: 'I think he's a future Grand Slam victor.
Gulbis will face either Nick Kyrgios or Kei Nishikori in the next round.
But the 21-year-old German has plenty of practice at scrambling out of trouble after three times winning from two sets to one down at the recent French Open.
Britain's Gove says Brexit plan is a realistic compromise
Mr Rees-Mogg refused to support her and said that "she would be well-advised to revisit her Brexit policy". We need to have quickly realistic and workable solutions".
Defending champion Garbine Muguruza was the biggest name to be sent packing on the fourth day of the tournament after little-known Belgian Alison van Uytvanck produced a fearless brand of hard-hitting tennis to win 5-7, 6-2, 6-1. Few are talking about the Argentinian as a potential victor next Sunday but he is still yet to drop a set.
"I'm glad that I went through it", Gulbis said.
"I know him a little bit, practised with him a bunch".
Crucially for his hopes there are no issues with the career-threatening wrist injury that kept him out during most of 2014 and 2015.
"Today I was returning much better, as I said, because it was brighter".
The match was sealed after two hours and 24 minutes with an ace, a loud cry of "Vamos!" and a kiss blown to the skies. Unfortunately that's it for me for this year. Raonic, the No. 13 seed from Thornhill, Ont., led 6-5 in the third set when play resumed.
And highest of all on that list?