Mourinho, who will be without the likes of Nemanja Matic, Antonio Valencia, Ander Herrera and Marcos Rojo on Friday, once again bemoaned the lack of preparation time for the start of the season, with many of his players having just returned to training after taking time off following the World Cup.
There's also a new name in the dugout, with Chelsea manager Maurizio Sarri taking charge of his first top flight match as Blues boss away at Huddersfield.
Real Madrid was already pursuing the Belgium goalkeeper before striking the €35-million ($52.45-million) fee with Chelsea.
"You are talking about Liverpool spending money this transfer window, City have spent very bad lot in the last few years and they are now getting the benefit under Pep Guardiola".
Hughton was hugely active in the transfer market in the summer, bringing in 16 new players and letting go another 18.
Manchester United coach, Jose Mourinho made no secret of his desire to sign the sturdy defender as he made an initial bid of £65m which was rejected by the club who demanded that they would only listen to offers from £100m.
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Meanwhile, defending champions Manchester City alongside Liverpool, Manchester United and probably Arsenal, Chelsea and Tottenham are considered favourites to win this competition at the end of the season in May 2019. They couldn't even sign a player from the Championship.
The game on Merseyside will be particularly interesting for African fans, with the Reds' Egyptian superstar, Mohamed Salah, hoping to continue from where he left off last season, while new signing, Guinea's Naby Keita, will also want to make a big impact on his Premier League debut.
The move however irked Guardiola who labelled Napoli president, Aurelio De Laurentiis' decision as unprofessional.
The summer window closed in England at 5pm on Thursday evening, with Liverpool one of few clubs enjoying a quiet deadline day after securing four key signings earlier in the summer. "We believe a lot in our players and why not repeat a similar season like a year ago or the season before, and with more experience?"
The 22-year-old was decent last year, but far from his best, and if Spurs are to challenge Man City this season, the enigmatic midfielder quite simply must rediscover his form from the 2016/17 campaign.
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Michael Eisenberg, director of male reproductive medicine and surgery at Stanford University School of Medicine, agreed. Higher levels of FSH indicate that the body is pushing the testes to produce more sperm as counts are low.