Gareth Southgate has expressed frustration about Phil Foden's lack of first-team involvement for Manchester City and warned England's senior players they can not expect to keep their places if they are not involved more regularly for their club sides.
England returned to winning ways with a narrow 1-0 victory over Switzerland in an global friendly on Tuesday.
"We could have been two or three-nil down at half-time", Danny Rose, the left back who was one of the few players to impress, said.
Kane is among the top strikers in the world, Rashford has plenty of potential but features mainly as a substitute for Manchester United, while Welbeck has a strong worldwide record but plays a bit-part at Arsenal.
Eric Dier, Ruben Loftus-Cheek and Fabian Delph will start in midfield, while Danny Welbeck joins Rashford up front.
Having had little time to impress in a Man United shirt this season, Rashford has taken the opportunity of the global break to remind English football fans of his talent.
"It was a tall order to ask them to play against an excellent Switzerland side, they kept the ball well and we had to chase too much".
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"He is happy to play wherever he can get game time and he is still getting stronger".
"I'm really pleased for him".
Southgate's concerns extend to Foden's restricted time on the pitch for City, with the 18-year-old limited to one substitute appearance, of eight minutes, this season.
'I was at Manchester City versus Huddersfield and you think, "well okay, it is a game where Phil Foden will play".
Daily Telegraph columnist Jamie Carragher made the point that Rashford has the most hard of tasks at United - a young player coming through as a striker at a big club. Southgate made sure not to say anything that could be perceived as critical of Pep Guardiola, but the England manager believes it is part of a wider problem that is squeezing out some of the country's better players.
"I think what is happening at junior level is that there is more emphasis on technical ability". We needed to keep him ticking over.