Buffon, 40, and compatriot Marco Verratti are both banned for the Anfield clash with last season's beaten finalists because of suspensions incurred last campaign, while Dani Alves and Layvin Kurzawa are both out injured - and US global Timothy Weah is not included.
Experienced Paris Saint-Germain goalkeeper Gianluigi Buffon has travelled with his teammates to Liverpool for Tuesday's opening Champions League Group C encounter despite the first of a three-match suspension for the Italian legend.
Without Kylian Mbappe and Neymar, PSG were still too hard to restrain for Saint-Etienne.
PSG's Edinson Cavani protest for a disallowed goal during their French League One football match between Paris-Saint-Germain and Saint-Etienne.
Since joining PSG it has been no surprise that the well-renowned manager has his side now sitting at the top of Ligue 1, five points clear of their nearest challengers Marseille, Lille and Toulouse.
"Not yet the 11th and I do not know my game system".
Australians warned to cut up strawberries after people report finding needles inside
A media spokeswoman for the Police Minister who was at the event said fortunately the Commissioner was aware of the incident. The needles in strawberry crisis has taken a sinister turn, with authorities suggesting there may now be copycat incidents.
Draxler was not to be denied in the 22nd minute as he put the Ligue 1 champions ahead with an exquisite header past Ruffier following a cross from Marco Verratti, 1-0.
Thomas Tuchel is set to rest Neymar this weekend when the Ligue 1 champions face St. Etienne in a bid to have the Brazilian at his very best after a taxing global break.
The world's most expensive player turned out for Brazil in midweek in a 5-0 friendly win over El Salvador in the United States and scored, as did PSG colleague Marquinhos.
Diaby, who replaced Lassana Diarra into the second half, paid off coach Thomas Tuchel' trust, as the 19-year-old player directed Di Maria to fire into the net, before capping the hosts' scoring extravaganza on Cavani's misfired shot with six minutes from time.
Earlier on Friday, Nice shook off the absence of Mario Balotelli as they came from behind to beat Rennes 2-1 on the Cote d'Azur.
France's other Champions League contenders are Monaco, who face in-form Toulouse away on Saturday night before hosting Atletico Madrid on Tuesday.