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"Turkey has a plan, Madam President, in Idlib and it does involve reaching an agreement with the Syrian opposition whereby the regime refrains from attacking them while they combat terrorism", she said referring to Nikki Haley, the U.S.'s United Nations envoy and council president.

"We've been in consultation with the British and the French, who joined us in the second strike, and they also agree that another use of chemical weapons will result in a much stronger response", Bolton was quoted by The Wall Street Journal as saying.

"We invite the global community to vocally and actively support our efforts to this end", Sinirlioğlu told the U.N. Security Council during a session on the Syrian province.

The province and its surrounding areas are the last major enclave held by rebels opposed to Syrian President Bashar al-Assad. On the contrary, they would create further suffering, alienate and radicalize more Syrians.

The United Nations warned last week that an operation would lead to the "worst humanitarian catastrophe in the 21st century".

Fighters from a coalition of Islamist forces celebrate on after taking the al-Mastumah base in the Syrian city of Idlib.

But he said Russia's President Vladimir Putin and Turkish President Tayyip Erdogan were working hard to find a solution.

About 2.9 million people live in the opposition-held area, which comprises most of Idlib province and adjacent small parts of Latakia, Hama and Aleppo provinces.

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Turkey is a leading opposition supporter which has troops in the country and has erected 12 observation posts around rebel-held Idlib. "It's just not my style", Mattis said when asked if and what kind of retaliation the U.S. military would carry out should the regime use chemical weapons in its offensive against Idlib.

"Russia, Iran and Assad are demolishing Idlib and asking us to call it peace", she said.

At the summit in Tehran, Erdogan, Russia's Vladimir Putin and Iran's Hassan Rouhani agreed in a statement that there could be no military solution to the conflict and it could only end through a negotiated political process.

Rebel militants, the Kremlin says, have already delivered the toxic substances, including chlorine, to the town of Jisr Al Shughour in Idlib.

OCHA spokesman David Swanson told Reuters that as of Sunday, 30,542 people had been displaced from northwest Syria, moving to different areas across Idlib.

"In Idlib, we're watching very closely what the Assad regime, aided and abetted by the Iranians and the Russians are up to", Mattis told Pentagon reporters.

Roughly half of the displaced are staying in camps, Dujarric said.

"In this sense, a military operation in Idlib would only play into the hands of terrorists", he said.