After the Supreme Court disqualified Nawaz Sharif from his seat a year ago, Kulsoom was elected to Lahore's NA-120 constituency in a bye-poll. She had married Sharif in April 1971.
She was diagnosed with lymphoma past year, barely a month after Nawaz Sharif was removed from office by the Supreme Court, which ordered him to face trial in an anti-corruption court.
The announcement of Kulsoom's demise was made on twitter by Nawaz's younger brother Shehbaz Sharif.
Kulsoom Nawaz passed away on Tuesday after a prolonged illness.
Jailed ex-premier Nawaz Sharif and daughter Maryam Nawaz are now in Adiala Jail, Rawalpindi, serving their sentences in the Avenfield corruption case; and were handed jail sentences of 10 years and seven years respectively.
Nawaz Sharif and Maryam were convicted in July by an anti-corruption court for not being able to prove the source of assets used to purchase a set of upmarket London apartments. According to reports, her health deteriorated on Monday night and she was placed on life support.
The newly elected Pakistani government of Imran Khan has made a decision to extend all help in bringing the mortal remains of Begum Kulsoom from London.
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Born in 1950, she was known for her reserved nature in public, serving as a quiet foil to her husband, who was elected as Pakistan's prime minister three times.
She was elected from Lahore's NA-120 constituency in a by-election after her husband was disqualified from the seat by the Supreme Court previous year but left for Britain even before she could start campaigning.
Begum Kulsoom served as first lady of Pakistan for three non-consecutive terms from 1990-1993, 1997-1999 and 2013-2017.
Arif Alvi condoled the bereaved family.
"We have conveyed to the Pakistan High Commission in London to fully cooperate with the (Sharif) family to bring back the body", Iftikhar Durrani, media adviser to the prime minister, told Arab News.
In her absence, Maryam ran her campaign.
"May Allah bless the departed soul eternal peace at Heaven", he remarked.
Former Pakistan Cricket Board chairperson Najam Sethi also expressed his grief.