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Britain's Billy Joe Saunders will give up his WBO world middleweight title "with a heavy heart" as he challenges the decision to deny him a licence, says promoter Frank Warren.

Saunders had been scheduled to face Demetrius Andrade in Boston for a middleweight title defense but now, that fight will no longer take place.

Eddie Hearn, who promotes Andrade, has said he would look to secure a bout for the vacant title in the event Saunders is stripped by the WBO. The WADA list distinguishes between substances prohibited "at all times" and substances prohibited "in competition".

Frank Warren, Saunders' promoter, revealed earlier Thursday that Saunders will appeal the MA commission's decision all the way to the U.S. Supreme Court, if necessary.

"Massachusetts have not even applied their own disciplinary regulations correctly, so obviously Bill will appeal and the appeal will go to the Supreme Court". Saunders' team are arguing that oxilofrine is only listed by WADA as a banned substance when it is found up within a day of competition. It's ridiculous. It's stupid where we are at with this. In September, Saunders was fined £100k by the British Boxing Board of Control for misconduct after a video was shared online in which Saunders offers a woman £150 worth of drugs to perform a sex act.

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Warren spoke to talkSPORT on Thursday regarding Saunders situation: "The Massachusetts State Athletic Commission, whose jurisdiction the fight takes place under, at their hearing yesterday they had said they had grounds for denial of his application for a license".

Kautondokwa (17-0 16KOs) has replaced Billy Joe Saunders in the bout with the unbeaten former Super-Welterweight World ruler, and "The Executioner" is full of belief that he can add to his formidable knockout record in MA having already been in camp. The low level of the chemical detected in the test supplied by Billy-Joe - ingested via a nasal spray - is not a prohibited substance when ingested "out of competition".The VADA test was conducted "out of competition" and so was not prohibited for the goal of the application of the WADA list and therefore the application of the MSAC rules to Billy-Joe.

Andrade took this fight extremely serious as he left his home on the east coast and relocated for a month and a half to the Bay Area to train at the private SNAC facility private gym.

But it is prohibited at all times by the Voluntary Anti-Doping Association, which tested Saunders on 30 August.