The hosts, who won the opening Test in Rajkot, have 15 overs in the day to blank West Indies 2-0 inside three days. Virat Kohli is back as the captain of the Indian One-day worldwide team for the initial two matches of the arrangement against the Windies. For India, the previous smallest lead to result in ten-wicket victory was also in Hyderabad: a lead of 104 runs, against New Zealand in 1988.
"We were looking at them playing with a lot of freedom, which they did", Kohli said after India's three-day, 10-wicket win on Sunday.
Coach Stuart Law has been suspended from West Indies' first two ODIs against India, and will not be able to be with the team in the dressing room.
For India, it was their 10th series win at home since their last defeat against England in 2012.
Out of the four innings in this series, West Indies couldn't cross the 200-run mark thrice which was a testimony to their plight during the series.
The tail-enders added 45 more, chiefly through Ashwin (35) as India folded for 367 taking a slender 56-run lead.
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The top scorers for India are Rishabh Pant (92), Ajinkya Rahane (80) and Prithvi Shaw (70).
Two suspension points equate to a ban from one Test or two ODIs or two T20Is, whatever comes first for the player or player support personnel.
West Indies captain Holder's five wickets briefly gave him the best average (11.87) for a fast bowler in a calendar year for 100 years (with 30 or more wickets).
Rahane featured in a 152-run stand with Pant, who could not reach triple figures thanks to a brilliant catch by Shimron Hetmyer. This time he played 134 balls hitting 11 boundaries and two sixes.
He is only the third pacer to clinch a fifer in a Test innings by an Indian bowler at home in the last 5 years after Mohammed Shami and Bhuvneshwar Kumar.