It was the first TD run the Bears have allowed this season, and it ended the Bills' touchdown drought at 187 minutes and 19 seconds - dating to Peterman's 16-yard pass to Zay Jones in a 20-13 loss at Houston on October 14.
The Bills then signed QB Derek Anderson off the street and promptly started him a week after signing him, only for Anderson to suffer an injury too.
Although they are huge favorites, the Bears will still need to play well to avoid what would be the biggest upset of the year.
It wasn't pretty against the Chicago Bears during a 41-9 loss. The more interesting notes might be who didn't have a chance to make much of an impact, like running back LeSean McCoy. If that's the case, can he be the spark the passing game needs?
"It's always great to go out and perform the way we did", linebacker Roquan Smith said.
Buffalo turned the ball over four times, including Nathan Peterman throwing three interceptions in his first start since a 47-3 season-opening loss at Baltimore.
Sam Ballard dead: How did Sam Ballard die? Promising rugby player dies
The NDIS said it had been "working closely with the Ballard family " to find a resolution and increase Sam's support package. An obituary posted in this morning's Sydney Morning Herald stated that his "army of friends" were at his side until the end.
Peterman could be motivated to prove that he is better than his past performances and look to upset the Bears as evidence.
Bears defensive end Khalil Mack is "unlikely" to play Sunday against the Bills, according to ESPN. He played at the University at Buffalo.
Yes, the Bills have the worst offense in the National Football League, but it has been nine weeks since opening day, when the Ravens beat them 47-3, that a team has destroyed them the way the Bears did Sunday. Wide receiver Allen Robinson's absence was replaced with the production of Anthony Miller and Josh Bellamy who combined for seven catches for 74 yards and a touchdown. The University at Buffalo product is one of the very best players in the game and if he does play, the Bills' offensive line will have their hands full, whether he's fully heathy or not.
In the meantime, though, things are as brutal as they have ever been in Buffalo.
Their fans are truly dedicated to supporting their home team as creating a hostile environment has motivated their team to upsets in years prior. He missed last week's game and most of practice this week with an ankle injury. He played the following week against the New England Patriots but was clearly not his same dominant self. If Buffalo's defense is holding the Bears offense to field goals than it is imperative for kicker Cody Parkey to convert on all of his attempts.