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United States fire department officials have reported multiple injuries in a shooting at a bar and dance hall in southern California.

There has been a mass shooting at a Californian bar, according to U.S. media reports.

A sheriff's captain says at least six people were shot late Wednesday when a suspect opened fire in a crowded Southern California bar.

Ventura County Sheriff's Deputies responded to the Borderline Bar and Grill at about 11:30 p.m.

It has not yet been revealed the extent of the injuries.

One witness said there were multiple shots fired inside the bar.

The Times reports that there were multiple reports of shots fired and people hit.

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He told reporters: "When our deputies arrive on the scene they attempted to neutralise that threat, I can't tell you if it was neutralised or not".

"Please stay away from area", the department urged in a tweet.

It is thought the gunman may still be at large and at least police officer is injured.

Officers later reported a man matching the suspect's description on the ground at the scene outside a window.

"The gunman was throwing smoke grenades all over the place", a different witness told KABC.

Victims rant to a nearby petrol station to get medical help.

It is reported to be "college night" at the bar, with some suggesting the attack was aimed at university students.